PE 22-28 10MG

Description

PE-22-28 (Mini-Spadin) PE-22-28 is a premier reagent for neuroscience research, specifically engineered to investigate the rapid modulation of the TREK-1 (K2P2.1) potassium channel. This synthetic heptapeptide is a refined “mini-Spadin” molecule, optimized from its parent peptide to achieve high-affinity targeting of neuronal membrane potential and hippocampal neurogenesis. Key Research Features

Selective Ion Channel Antagonism: Acts as a highly specific inhibitor of TREK-1, the background potassium leak channel responsible for regulating resting membrane potential and neuronal excitability. Rapid-Onset Mechanism: Designed to study accelerated antidepressant-like responses, demonstrating efficacy in mammalian models within 4 days by overriding inhibitory autoreceptors and increasing serotonergic firing rates. Neurogenic Stimulator: A critical tool for researching the upregulation of Brain-Derived Neurotrophic Factor (BDNF) and the proliferation of progenitor cells in the dentate gyrus. Neuroprotective Modeling: Specifically used to investigate survival pathways (PI3K/Akt and MAPK/ERK) that may reduce infarct volume and apoptotic signaling following ischemic stroke events.

Technical Specifications

Sequence: Gly-Val-Ser-Trp-Gly-Leu-Arg (GVSWGLR)

Molecular Weight: ~773.89 Da to 802.94 Da

Target Affinity: IC50 of ~0.12 nM (Highly Potent) Format: Lyophilized powder Selectivity: High selectivity for TREK-1 over related K2P channels (TREK-2, TRAAK) and the cardiac hERG channel.

Applications in Research

Mood Disorder Modeling: Investigating non-monoaminergic pathways for treating Major Depressive Disorder (MDD) and treatment-resistant phenotypes. Neuroplasticity Studies: Analyzing the restoration of synaptic markers like PSD-95 and the reversal of stress-induced cognitive atrophy. Ischemia & Stroke Research: Evaluating the peptide’s ability to protect neuronal integrity and improve neurological scores in ischemia/reperfusion laboratory models.

Research Use Only – Legal Disclaimer

All Eagle Peptides products labeled as Research Use Only (RUO) are intended strictly for laboratory, investigational, and scientific research purposes. These materials are not approved by the FDA and are not intended for human or veterinary use, clinical applications, diagnostic procedures, or therapeutic treatment of any kind. By purchasing or using RUO materials, you acknowledge that they will be handled only within an appropriate research environment by qualified personnel who understand the risks, limitations, and regulatory requirements associated with experimental compounds. Products must not be administered to humans or animals, offered as therapeutic agents, or represented as safe or effective for any medical purpose. Use of these materials is entirely at your own risk. Eagle Peptides assumes no liability for misuse, unsafe handling, improper application, or any regulatory or compliance issues arising from their use.